Ethyl diazoacetate
Ethyl diazoacetate
CAS: 623-73-4
Molecular Formula: C4H6N2O2
Ethyl diazoacetate - Names and Identifiers
Ethyl diazoacetate - Physico-chemical Properties
| Molecular Formula | C4H6N2O2 |
| Molar Mass | 114.1 |
| Density | 1.085 g/mL at 25 °C (lit.) |
| Melting Point | -22 °C (lit.) |
| Boling Point | 140-141 °C/720 mmHg (lit.) |
| Flash Point | 115°F |
| Merck | 13,3021 |
| BRN | 107654 |
| Storage Condition | 2-8°C |
| Refractive Index | n20/D 1.46(lit.) |
| Physical and Chemical Properties | This product is a colorless liquid, M.P.-22 ℃, B. p.140 ~ 141 ℃/96 kpa,n20D 1.4800, relative density 1.085,f. P. 80 F (26 C), insoluble in water, soluble in dichloroethane and other solvents. |
Ethyl diazoacetate - Risk and Safety
| Risk Codes | R5 - Heating may cause an explosion R10 - Flammable R22 - Harmful if swallowed R40 - Limited evidence of a carcinogenic effect R67 - Vapors may cause drowsiness and dizziness R65 - Harmful: May cause lung damage if swallowed R48/20 - R38 - Irritating to the skin R11 - Highly Flammable R63 - Possible risk of harm to the unborn child |
| Safety Description | S36/37 - Wear suitable protective clothing and gloves. S62 - If swallowed, do not induce vomitting; seek medical advice immediately and show this container or label. S16 - Keep away from sources of ignition. |
| UN IDs | UN 1993 3/PG 3 |
| WGK Germany | 3 |
| RTECS | AG5775000 |
| HS Code | 29270000 |
| Hazard Class | 3.2 |
| Packing Group | III |
Ethyl diazoacetate - Reference Information
| NIST chemical information | information provided by: webbook.nist.gov (external link) |
| Use | ethyl diazoacetate is an important intermediate for the preparation of chrysanthemum acid or dichloromethane chrysanthemum acid. used in organic synthesis. |
| production method | is obtained by reacting glycine ethyl ester hydrochloride with sodium nitrite. The preparation method is to dissolve sodium nitrite in water and add it to the reactor with dichloroethane as the solvent to maintain the temperature of 18~20 ℃, then, the pH of the aqueous solution of glycine ethyl ester hydrochloride is adjusted to 1 with dilute sulfuric acid, and the solution is added dropwise to the sodium nitrite solution, and the temperature of the solution is maintained at 18~20 ° C. After the dropwise addition is completed, the mixture was further stirred for 0.5h, and the organic layer was separated. The aqueous layer was extracted with dichloroethane for 1 time, and the oil layer was combined, that is, the dichloroethane solution of ethyl diazoacetate was prepared for the production of chrysanthemum acid or dichloro chrysanthemum acid. It is also possible to dissolve glycine ethyl ester hydrochloride in a buffer solution consisting of acetic acid and sodium acetate, then add dichloroethane as a solvent, and add sodium nitrite solution Dropwise at 10~15 ℃, stirring was continued for another 15 min, and the organic layer was separated as a solution of ethyl diazoacetate in dichloroethane. Reaction equation: NH2CH2COOC2H5 · HCl NaNO2 HCl → N2CHCOOC2H5 NaCl H2O |
| category | flammable liquid |
| toxicity grade | high toxicity |
| Acute toxicity | oral-rat LDL0: 400 mg/kg |
| explosive hazard characteristics | high thermal explosion |
| flammability hazard characteristics | in case of open flame, high temperature, flammable oxidant; Toxic nitrogen oxide smoke generated by combustion; decomposition of toxic nitric oxide gas in case of acid |
| storage and transportation characteristics | The warehouse is ventilated and dried at low temperature; Stored separately from oxidants and acids |
| extinguishing agent | dry powder, dry sand, carbon dioxide, foam, 1211 extinguishing agent |
Last Update：2024-04-09 02:00:10
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CAS: 623-73-4
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CAS: 623-73-4
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